What is avanafil (Stendra)? Uses, Dosage, Side Effects, Interactions

Avanafil is utilized to treat erectile dysfunction (powerlessness to get or keep an erection in men). Avanafil is in a class of meds called phosphodiesterase (PDE) inhibitors. It works by expanding blood stream to the penis during sexual stimulation. This expanded blood stream can cause an erection. Avanafil doesn't fix erectile dysfunction or increases sexual longing. Avanafil doesn't forestall pregnancy or the spread of sexually transmitted diseases like human immunodeficiency virus (HIV).

Formula: C₂₃H₂₆ClN₇O₃

Molar mass: 483.951 g/mol

ChemSpider ID: 8045620

Trade name: Stendra

PubChem CID: 9869929

ChEBI ID: 66876

What are the uses of Avanafil?

It is used by men to treat erectile dysfunction as this medication helps to get and keep an erection. Avanafil is an orally accessible phosphodiesterase type 5 (PDE5) inhibitor with vasodilatory action. Avanafil specifically represses PDE5, accordingly restraining the degradation of cyclic guanosine monophosphate (cGMP) found in the smooth muscle of the corpus cavernosa of the penis. The restraint of cGMP degradation brings about delayed muscle unwinding, vasodilation, and blood engorgement of the corpus cavernosa, along these lines bringing penile erection.

Doses of Avanafil (Stendra):

Avanafil comes as a tablet to take by mouth. For men taking the 100-mg or 200-mg portions, avanafil is typically taken with or without food depending on the situation, around 15 minutes before sexual movement. For men taking the 50-mg portion, avanafil is normally taken with or without food on a case-by-case basis, around 30 minutes before sexual action. Try not to take avanafil more regularly than once in 24 hours. Follow the headings on your medicine mark cautiously and ask your PCP or drug specialist to clarify any part you don't comprehend. Take avanafil precisely as coordinated. Try not to take more of it or take it more frequently than endorsed by your primary care physician.

Your primary care physician will likely be beginning you on a normal portion of avanafil and may increase or lower your portion contingent upon how you react to the drug. Tell your PCP if avanafil isn't functioning admirably or on the off chance that you experience harmful effects.

Prior to taking Avanafil:

• A few drugs are not reasonable for individuals with specific conditions, and once in a while a medication may possibly be utilized if additional consideration is taken. Hence, before you begin taking avanafil it is significant that your primary care physician knows:
• In the event that you have an irregular heartbeat, a heart condition, or blood vessel illness.
• On the off chance that you have any illness, injury or deformity of your penis.
• In the event that you have had an eye condition causing loss of vision.
• On the off chance that you have any issues with the way your liver works or with the manner in which your kidneys work.
• On the off chance that you have had a stroke or a coronary failure.
• On the off chance that you have high or low circulatory strain, or angina.
• In the event that you have sickle cell disease
• In the event that you have at any point had bone marrow cancer or leukemia.
• On the off chance that you are taking or utilizing some other prescriptions. This incorporates any medications you are taking which are accessible to purchase without a prescription, just as herbal and corresponding prescriptions, and recreational medications.
• On the off chance that you have a condition which causes bleeding, like a stomach ulcer.
• In the event that you have at any point had a hypersensitive response to a medication.

Side Effects of Avanafil (Stendra):

• Headache
• Stomach Upset
• Back Pain
• Nausea
• Dizziness
• Flushing
• Diarrhea
• Prolonged Or Painful Erections
• Painful Urination
• Blurry Vision
• Constipation
• Stuffy Nose
• Runny Nose

Interactions:

• Abametapir
• Amyl Nitrite
• Fosamprenavir
• Idelalisib
• Imatinib
• Cobicistat
• Conivaptan
• Darunavir
• Enzalutamide
• Eslicarbazepine Acetate
• Chloramphenicol
• Isosorbide Dinitrate
• Apalutamide
• Atazanavir
• Clarithromycin
• Isosorbide Mononitrate
• Nitroglycerin Po
• Nitroglycerin Rectal
• Itraconazole
• Nitroglycerin Iv
• Nitroglycerin Transdermal
• Nitroglycerin Translingual
• Nitroglycerin Sublingual
• Nitroglycerin Topical
• Riociguat
• Vericiguat

How could this medication be utilized?

You and your accomplice will in any case have to take part in foreplay, similarly as you would in the event that you were not taking a medication for erectile dysfunction. Avanafil won't cause an erection except if you are aroused sexually.

Try not to drink a lot of liquor before you intend to take avanafil. Drinking an excess of liquor can diminish your capacity to get an erection and this may keep you from getting the greatest profit by the tablets. The blend of avanafil and liquor will likewise build your risk of harmful effects like dizziness.

It is suggested that you don't drink grapefruit juice during the 24 hours before you take avanafil. This is on the grounds that there is a substance in grapefruit juice which can expand the measure of avanafil in your circulatory system and this makes harmful effects more probable.

Keep your ordinary meetings with your PCP so your progress can be checked. On the off chance that you feel the tablets are excessively strong for you, talk about this with your PCP as your portion may should be decreased. On the other hand, on the off chance that you don't get an erection subsequent to taking avanafil, or on the off chance that it doesn't keep going long enough for you to engage in sexual relations, you ought to examine this with your primary care physician - don't take a greater number of tablets than you have been advised to.

You ought not take Avanafil in the event that you are utilizing some other items or taking some other medications to treat erectile dysfunction.

Storage:

Store this medicine at room temperature. Store the medicine between the temperature of 15-25ºC  in the original packaging. Keep this medicine away from people above 65 years of age, children or pets. Always keep a check on the expiry date of this medicine and, do not eat this medicine if it is expired.